Laboratory of General Biochemistry and Physical Pharmacy

Elnaz Shaabani

Elnaz

 

 

 

 

 

 

Contact

Laboratory for General Biochemistry and Physical Pharmacy
Ghent University
Ottergemsesteenweg 460
9000 Gent
Belgium
Tel: 0032 9 264 80 47 (secretary)
Tel: 0032 9 264 80 49 (direct)
E-mail:

 

Biography

Elnaz Shaabani Sichani obtained her degree in Radiologic technology (B. Sc.) in 2013 at the Shahrekord University of Medical Sciences (IRAN) with great distinction.
Subsequently, she performed her master thesis with the title ‘Synthesis of gold nanoparticles using curcumin and investigating their antioxidant effect on Beta-TC-3 cell line under the induction of diabetes conditions’ under the supervision of Prof. Sharmin Kharrazi in the School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences (TUMS) and graduated in 2017.
In October 2017, she started her Ph.D. in the same university under the supervision of Prof. Reza Faridi-Majidi, focusing on the design of nanocarrier for siRNA delivery in diabetic wound healing.
In September 2019 she joined Ghent University (Laboratory for General Biochemistry and Physical Pharmacy) as an Exchange student under the supervision of Prof. Kevin Braeckmans for the evaluation of endosomal escape of gene delivery and contributing to ongoing projects on light-triggered drug delivery.

 

Summary of research project(s)

Each person with diabetes has a 25% chance of developing a foot ulcer in his lifetime and many of them also lead to amputation. The lack of wound healing in diabetic patients is related to several factors, but it can be said that it is particularly affected by the degradation and infertility of microvascular, and subsequent development of ischemia. By the lack of new vasculature and the secretion of growth factors, the wound healing process is impaired. The aim of her research in the Ph.D. thesis is to overcome these obstacles with siRNA delivery with nanocarrier for increasing angiogenesis and after that encapsulate them in a nanofiber substrate for controlling nanoparticle release during topical administration in wound dressing.